ABSTRACT
Objective To investigate the curative effect of mesalamine combined with trimebutine maleate in the treatment of diarrhea predominant irritable bowel syndrome .Methods According to the digital table ,112 patients with diarrhea predominant irritable bowel syndrome were randomly divided into control group and observation group , 56 cases in each group .The two groups were given conventional symptomatic treatment ,on this basis ,the control group recieved mesalamine treatment ,the observation group recieved mesalamine combined with trimebutine maleate treat -ment.The two groups were treated for 4 consecutive weeks.The main indicators,clinical efficacy and adverse reaction of the two groups were compared .Results The total effective rate of the observation group was 94.6％,which was significatnly higher than 78.6％of the control group (χ2 =3.925,P<0.05).The antidiarrheal time,stool recovery time between the two groups had statistically significant differences (t=19.337,18.068,all P<0.05).The mental status,emotional status,diet and sleep status in the two groups were all improved ,the differences were statistically significant(all P<0.05),which in the observation group improved more significantly than that in the control group , the differences were statistically significant(all P<0.05).The two groups had no other serious adverse reactions . Conclusion On the basis of conventional treatment ,mesalamine combined with trimebutine maleate in the treatment of diarrhea predominant irritable bowel syndrome can significantly improve clinical symptoms ,improve clinical curative effect,and it has good safety and great clinical significance .
ABSTRACT
Objective To investigate the correlation of endoscopic and pathological diagnosis of chronic atrophic gastritis( CAG) . Methods 108 patients diagnosed as CAG by gastroscopy were selected. Whether the results were consistent with the diagnosis between gastroscope and pathology were observed, and the diagnosis relationship between gastroscopic and histopathological features,and the relationship between CAG and Hp were observed,and the coincidence rates of the diagnostic results by using these two methods were calculated. Results 19 cases of chronic superficial gastritis( CSG) and 89 cases of CAG were diagnosed by pathologic biopsy,and 42 cases of CAG with intes-tinal metaplasia,13 cases with dysplasia. The coincidence rate of CAG between gastroscopic and pathological diagnosis was 82. 41%. 9 cases showed the gastric mucosa in rough and showed granular or nodular changes,meanwhile,7 cases of them with CAG were confirmed by histopathology , following 3 cases of them with intestinal metaplasia ( 33 . 33% ) and 1 case of them with heterosexual hyperplasia(11. 11%). 18 cases showed the change of the color of the gastric mucosa with red and white,and mainly in white,following vascular exposure tested by gastroscope. 13 cases of them (72. 22%) with CAG were confirmed by histopathology,4 cases of them with intestinal metaplasia(22. 22%) and 1 case of them with heterosexual hyperplasia(5. 56%). 14 cases showed gastric mucosal folds flat,thinning or even disappear tested by gastroscope. 10 cases of them(71. 43%) with CAG were confirmed by histopathology,following 4 cases of them with intestinal metaplasia(28. 57%) and 2 cases of them with heterosexual hyperplasia(14. 29%). When the three manifestations of gastroscope were presented,the CAG coincidence rate was more than 70. 00%,and the highest was the rough gastric mucosa with the rate of 77. 78%. When the any two of the manifestations of gastroscope were simultaneously presented,the CAG coincidence rate was more than 80. 00%,and the highest was the rough gastric mucosa and the color of red and white combination with the rate of 88. 00%. When the three of the manifestations of gastroscope were simultaneously presented,the CAG coincidence rate was more than 80. 00%. Hp was positive in 55 cases(50. 93%). 89 cases were diagnosed by pathology,48 cases of them(53. 93%) were Hp positive. In the 42 cases with intestinal metaplasia,24 cases of them(57. 14%) were Hp positive. In 13 cases with dysplasia,9 cases of them(69. 23%) were Hp positive. Conclusion It should be combined with gastroscopy and pathological examination in clinic,and should pay more attention to the typical site biopsy and strengthen the identify of endoscopic morphology, and also standardize the endoscopic operation. It can ultimately improve the diagnostic coincidence rate of the two methods.
ABSTRACT
Objective To investigate the correlation of endoscopic and pathological diagnosis of chronic atrophic gastritis( CAG) . Methods 108 patients diagnosed as CAG by gastroscopy were selected. Whether the results were consistent with the diagnosis between gastroscope and pathology were observed, and the diagnosis relationship between gastroscopic and histopathological features,and the relationship between CAG and Hp were observed,and the coincidence rates of the diagnostic results by using these two methods were calculated. Results 19 cases of chronic superficial gastritis( CSG) and 89 cases of CAG were diagnosed by pathologic biopsy,and 42 cases of CAG with intes-tinal metaplasia,13 cases with dysplasia. The coincidence rate of CAG between gastroscopic and pathological diagnosis was 82. 41%. 9 cases showed the gastric mucosa in rough and showed granular or nodular changes,meanwhile,7 cases of them with CAG were confirmed by histopathology , following 3 cases of them with intestinal metaplasia ( 33 . 33% ) and 1 case of them with heterosexual hyperplasia(11. 11%). 18 cases showed the change of the color of the gastric mucosa with red and white,and mainly in white,following vascular exposure tested by gastroscope. 13 cases of them (72. 22%) with CAG were confirmed by histopathology,4 cases of them with intestinal metaplasia(22. 22%) and 1 case of them with heterosexual hyperplasia(5. 56%). 14 cases showed gastric mucosal folds flat,thinning or even disappear tested by gastroscope. 10 cases of them(71. 43%) with CAG were confirmed by histopathology,following 4 cases of them with intestinal metaplasia(28. 57%) and 2 cases of them with heterosexual hyperplasia(14. 29%). When the three manifestations of gastroscope were presented,the CAG coincidence rate was more than 70. 00%,and the highest was the rough gastric mucosa with the rate of 77. 78%. When the any two of the manifestations of gastroscope were simultaneously presented,the CAG coincidence rate was more than 80. 00%,and the highest was the rough gastric mucosa and the color of red and white combination with the rate of 88. 00%. When the three of the manifestations of gastroscope were simultaneously presented,the CAG coincidence rate was more than 80. 00%. Hp was positive in 55 cases(50. 93%). 89 cases were diagnosed by pathology,48 cases of them(53. 93%) were Hp positive. In the 42 cases with intestinal metaplasia,24 cases of them(57. 14%) were Hp positive. In 13 cases with dysplasia,9 cases of them(69. 23%) were Hp positive. Conclusion It should be combined with gastroscopy and pathological examination in clinic,and should pay more attention to the typical site biopsy and strengthen the identify of endoscopic morphology, and also standardize the endoscopic operation. It can ultimately improve the diagnostic coincidence rate of the two methods.